HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl 2-azido-3-(5-bromothiophen-2-yl)acrylate → ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl 2-azido-3-(5-bromothiophen-2-yl)acrylate | HCID 73166977 | — |
| Lösungsmittel | O-Xylene | HCID 7237 | — |
| Produkt | ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate | HCID 13164349 | 82% |
Reaktionsschritte
Acrylate 60 (3.81 g, 12.6 mmol) in o-xylene was refluxed for 20 min. After removing the o-xylene, the crude product was purified by column chromatography (EtOAc/Hexane: 1/10) to give carboxylate 61 (2.83 g, 82%) as a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09290512B2 |
| Quelldatensatz | uspto-grants-2016_03 |
| ORD ID | ord-c3dcae264c9d41bf87b18a0dccf7e3e8 |
| Quellennotiz | uspto-grants-2016_03 |