6-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline → 3-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-2,4-dichloroquinoline

HRID 928734

Reaktionsgleichung

Reaktionsgleichung von HRID 928734
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:12])[C:6]([CH2:13][C:14]1[CH:19]=[CH:18][C:17](Cl)=[CH:16][CH:15]=1)=[C:5]2[Cl:21].[S:22]1C(CC(C(O)=O)C(O)=O)=C[C:24]2C=CC=C[C:23]1=2>>[S:22]1[C:14]([CH2:13][C:6]2[C:7]([Cl:12])=[N:8][C:9]3[C:4]([C:5]=2[Cl:21])=[CH:3][C:2]([Br:1])=[CH:11][CH:10]=3)=[CH:19][C:18]2[CH:17]=[CH:16][CH:15]=[CH:24][C:23]1=2

Komponenten

3

Edukt 2

HCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline3×HCID 867155902-(Benzo[b]thiophen-2-ylmethyl)malonic acid2×

Produkt 1

HCID 867155913-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-2,4-dichloroquinoline

Versuchsvorschrift

The title compound was prepared by substituting 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b) with 2-(benzo[b]thiophen-2-ylmethyl)malonic acid (Intermediate 10: step b) then following the procedure described for the preparation of 6-bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline (Intermediate 3: step c).

Quellen und Nachweise

ORD-Eintrag
ord-321149f6dc8c4704b33d298ac4bea3e0
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09290476B2

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