Ac-430 → HCID 178419998, Verbindung
Reaktionsgleichung
FC1C=CC([C@@H]([C:10]2[N:19]=[C:18](NC3C=C(C)NN=3)[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)O)=CC=1.FC1C=CC(C(C2N=C([NH:46][C:47]3[CH:51]=[C:50](C)[NH:49][N:48]=3)C3C(=CC=CC=3)N=2)O)=CC=1>>[NH:49]1[CH:50]=[CH:51][C:47]([NH:46][C:10]2[N:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)=[N:48]1Komponenten
3
Versuchsvorschrift
or an isotopic variant thereof; or pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof. (S)-(4-Fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol was determined to be the (−) isomer of (4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol by optical rotation analysis.
Quellen und Nachweise
- ORD-Eintrag
- ord-9d7d7f4a5276439ab83150f2bb8ec27e
- Quelldatensatz
- uspto-grants-2016_03