IN2-(benzyloxycarbonyl)-N6-(tert-butoxycarbonyl)-L-lysine → Z-Lys(boc)-ome

HRID 929404

Reaktionsgleichung

Reaktionsgleichung von HRID 929404
[NH:1]([C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])[C@H:2]([C:15]([OH:17])=[O:16])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].N(C(OC(C)(C)C)=O)[C@H:29](C(OC)=O)CCCCNC(OCC1C=CC=CC=1)=O>>[CH2:21]([O:20][C:18]([NH:1][C@@H:2]([CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[C:15]([O:17][CH3:29])=[O:16])=[O:19])[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Komponenten

3

Edukt 2

HCID 98765IN2-(benzyloxycarbonyl)-N6-(tert-butoxycarbonyl)-L-lysineHCID 11132998Boc-L-Lys(Z)-OMe

Produkt 1

HCID 13943124Z-Lys(boc)-ome

Versuchsvorschrift

The title compound was prepared from Z-L-Lys(Boc)OH by following the procedure described for example 4, intermediate 31. Intermediate 49 was characterized by the following spectroscopic data: 1H NMR (DMSO-d6, 300 MHz) δ (ppm) 7.47 (m, 5H), 6.76 (t, 1H), 5.09 (s, 2H), 4.51 (m, 1H), 3.68 (s, 3H), 3.18 (m, 2H), 1.90 (m, 2H), 1.55 (m, 2H), 1.38 (s, 9H), 1.25 (m, 2H).

Quellen und Nachweise

ORD-Eintrag
ord-36658c43afad45e286dcfeca4521230d
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09295732B2

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