2,2-Dimethoxypropane → (R)-4-(2-iodoallyl)-2,2-dimethyl-1,3-dioxolane
Reaktionsgleichung
[CH3:1][O:2][C:3]([O:6][CH3:7])([CH3:5])[CH3:4].C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.[I:25][C:26](=[CH2:32])[CH2:27][C@@H](O)CO>ClCCl>[I:25][C:26](=[CH2:27])[CH2:32][C@@H:1]1[CH2:7][O:6][C:3]([CH3:5])([CH3:4])[O:2]1Komponenten
5
Versuchsvorschrift
2,2-Dimethoxypropane and pyridinium p-toluenesulfonate (PPTS) are added to a solution of (R)-4-iodopent-4-ene-1,2-diol in dichloromethane and the mixture stirred at room temperature for 2 hours. Solvents are removed under reduced pressure and the crude product purified by flash chromatography using ethyl acetate/hexane (1:10) eluant.
Aufarbeitung
- customSolvents are removed under reduced pressure
- customthe crude product purified by flash chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-df3d582ce6f64e0897c9dec0bc495a02
- Quelldatensatz
- uspto-grants-2016_03
- Patentnummer
- US09296686B2
Notizen zur Reaktion
Wird geladen…