Thionyl Chloride → 4-(N,N-diethylcarbamoyl)benzhydryl chloride

HRID 929652

Reaktionsgleichung

Reaktionsgleichung von HRID 929652
[CH2:1]([N:3]([CH2:20][CH3:21])[C:4]([C:6]1[CH:19]=[CH:18][C:9]([CH:10](O)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=1)=[O:5])[CH3:2].S(Cl)([Cl:24])=O>ClCCl>[CH2:1]([N:3]([CH2:20][CH3:21])[C:4]([C:6]1[CH:19]=[CH:18][C:9]([CH:10]([Cl:24])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=1)=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 105409664-(N,N-diethylcarbamoyl)benzhydryl alcohol

Produkt 1

HCID 107330954-(N,N-diethylcarbamoyl)benzhydryl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The 4-(N,N-diethylcarbamoyl)benzhydryl alcohol (61.35 g, 216.5 mmol) was dissolved in 1500 mL of dichloromethane and 23.69 mL (324.8 mmol) of thionyl chloride was added dropwise. The reaction solution was stirred overnight at room temperature and the solvent was removed under vacuum. The crude product was redissolved in 800 mL of toluene and the solvent again was removed under vacuum to eliminate excess thionyl chloride, providing crude 4-(N,N-diethylcarbamoyl)benzhydryl chloride as a dark oil. Crude yield=100%.

Aufarbeitung

  1. customthe solvent was removed under vacuum
  2. dissolutionThe crude product was redissolved in 800 mL of toluene
  3. customthe solvent again was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-401efd2cf8fd4a3e9b6248fbbcc7eb6f
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09296707B2

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