3-(Bromomethyl)-2-chloropyridine → 3-[4-(2-Chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

HRID 929759Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 929759
[CH2:1]([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=2)[CH:7]=1)=[O:5])[CH3:2].Br[CH2:19][C:20]1[C:21]([Cl:26])=[N:22][CH:23]=[CH:24][CH:25]=1>>[CH2:1]([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH2:19][C:20]3[C:21]([Cl:26])=[N:22][CH:23]=[CH:24][CH:25]=3)=[CH:15][CH:16]=2)[CH:7]=1)=[O:5])[CH3:2]

Komponenten

3

Edukt 2

HCID 189310283-(Bromomethyl)-2-chloropyridineHCID 136133842Ethyl 3-(4-hydroxyphenyl)isoxazole-5-carboxylate2×

Produkt 1

HCID 902025533-[4-(2-Chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

Versuchsvorschrift

3-(4-Hydroxy-phenyl)-isoxazole-5-carboxylic acid ethyl ester (which may be prepared as described in Preparation of Intermediate 1) and 3-bromomethyl-2-chloro-pyridine (which may be prepared as described in Selby, T. P. and Winters, M. P. U.S. Pat. No. 5,739,326 Column 19) were reacted using conditions similar to those described for Preparation of Intermediate 24 to give 3-[4-(2-chloro-pyridin-3-ylmethoxy)-phenyl]-isoxazole-5-carboxylic acid ethyl ester.

Aufarbeitung

  1. custom5,739,326 Column 19) were reacted

Quellen und Nachweise

ORD-Eintrag
ord-7d4d68a38fee4b21b104ed3e45d58398
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09296711B2

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