6-Chloropyridin-3-yl-hydrazine dihydrochloride → HCID 89609966, Verbindung
Reaktionsgleichung
[Li].[Br:2][C:3]1[CH:4]=[C:5]([C:14]([O-])=[CH:15][C:16](=O)[C:17]([O:19]CC)=[O:18])[CH:6]=[C:7]([O:9][C:10]([F:13])([F:12])[F:11])[CH:8]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(O)=O)C=2)C=C(F)C=1.Cl.Cl.[Cl:48][C:49]1[N:54]=[CH:53][C:52]([NH:55][NH2:56])=[CH:51][CH:50]=1>>[Br:2][C:3]1[CH:4]=[C:5]([C:14]2[N:55]([C:52]3[CH:53]=[N:54][C:49]([Cl:48])=[CH:50][CH:51]=3)[N:56]=[C:16]([C:17]([OH:19])=[O:18])[CH:15]=2)[CH:6]=[C:7]([O:9][C:10]([F:11])([F:12])[F:13])[CH:8]=1Komponenten
4
Versuchsvorschrift
280 mg (0.72 mmol) of the compound of Example 5A is reacted analogously to the synthesis of the compound of Example 20A with 171 mg (0.79 mmol) of 6-chloropyridin-3-yl-hydrazine dihydrochloride. After hydrolysis, 202 mg (61% of theory) of the title compound is obtained.