methyl 4-chloro-1-isopropyl-1H-pyrazole-3-carboxylate → HCID 19619889, Verbindung

Reaktionsgleichung

FC(F)(F)COC1C(C(N)=O)=NC=CC=1.[Cl:16][C:17]1[C:18]([C:25]([O:27]C)=[O:26])=[N:19][N:20]([CH:22]([CH3:24])[CH3:23])[CH:21]=1>>[Cl:16][C:17]1[C:18]([C:25]([OH:27])=[O:26])=[N:19][N:20]([CH:22]([CH3:23])[CH3:24])[CH:21]=1

Komponenten

Edukt 2

HCID 50896795methyl 4-chloro-1-isopropyl-1H-pyrazole-3-carboxylate

HCID 66644029HCID 66644029, Verbindung

Produkt 1

HCID 19619889HCID 19619889, Verbindung

Versuchsvorschrift

Using an analogous reaction to that described for Intermediate 5, step 2 methyl 4-chloro-1-isopropyl-1H-pyrazole-3-carboxylate was converted into the title compound. MS m/z=188.9 [M+H]+. Calculated for C7H9ClN2O2: 188.035. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.41 (d, J=6.65 Hz, 6 H) 4.52 (quin, J=6.70 Hz, 1 H) 8.17 (s, 1 H) 12.89 (br. s., 1 H)

Aufarbeitung

customan analogous reaction to

Quellen und Nachweise

ORD-Eintrag: ord-a11fda627cca4fe28342e6c72fd14ed8
Quelldatensatz: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09296734B2

Notizen zur Reaktion

Wird geladen…