p-Toluenesulfonic acid → 6-(3-Hydroxyoxetan-3-yl)picolinaldehyde

HRID 931088Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 931088
[O:1]1CCO[CH:2]1[C:6]1[N:11]=[C:10]([C:12]2([OH:16])[CH2:15][O:14][CH2:13]2)[CH:9]=[CH:8][CH:7]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(C)=O>[OH:16][C:12]1([C:10]2[N:11]=[C:6]([CH:2]=[O:1])[CH:7]=[CH:8][CH:9]=2)[CH2:15][O:14][CH2:13]1

Komponenten

4

Edukt 2

HCID 6101p-Toluenesulfonic acidHCID 89853573HCID 89853573, Verbindung

Produkt 1

HCID 898538636-(3-Hydroxyoxetan-3-yl)picolinaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A solution of 3-(6-(1,3-dioxolan-2-yl)pyridin-2-yl)oxetan-3-ol (67 mf, 0.30 mmol) and p-toluenesulphonic acid (14.8 mg, 0.26 mmol) in acetone (3.00 mL) was heated to 50° C. and stirred for 18 h. The reaction mixture was cooled to room temperature. The solvent was removed under reduced pressure to afford the title compound. The material was used without further purification. MS (ES+) (M+H) 180.0; LCMS retention time: 1.57 minutes (Method L).

Aufarbeitung

  1. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6f07fe5e01cd4d50a70cd445a0a38a1f
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09296745B2

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