Sodium ethoxide → Ethyl 6-cyclopropylpyrazine-2-carbimidate

HRID 931107Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 931107
[O-:1][CH2:2][CH3:3].[Na+].[CH:5]1([C:8]2[N:13]=[C:12]([C:14]#[N:15])[CH:11]=[N:10][CH:9]=2)[CH2:7][CH2:6]1>C(O)C>[CH:5]1([C:8]2[N:13]=[C:12]([C:14](=[NH:15])[O:1][CH2:2][CH3:3])[CH:11]=[N:10][CH:9]=2)[CH2:7][CH2:6]1

Komponenten

4

Edukt 2

HCID 2723922Sodium ethoxideHCID 898540196-Cyclopropylpyrazine-2-carbonitrile

Produkt 1

HCID 89853280Ethyl 6-cyclopropylpyrazine-2-carbimidateAusbeute 126,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Sodium ethoxide (140 mg, 2.06 mmol) was added to a solution of 6-cyclopropylpyrazine-2-carbonitrile (150 mg, 1.03 mmol) in ethanol (6 mL) at room temperature. The reaction mixture was stirred at room temperature for 1 h. The solvent was removed under reduced pressure. The residue was partitioned between water and ethyl acetate. The organics were dried over sodium sulfate and concentrated under reduced pressure to afford the title compound (250 mg). MS (ES+) (M+H) 192.1012

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customThe residue was partitioned between water and ethyl acetate
  3. dry with materialThe organics were dried over sodium sulfate
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ba63df32974e4e66958fbfae49e03872
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09296745B2

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