8-(4-Chlorophenyl)-7-methoxy-6-methylquinoline → 8-(4-Chlorophenyl)-6-methylquinolin-7-ol
Reaktionsgleichung
ClC1C=C2C(C=CC(C)=N2)=CC=1O.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[C:22]([O:32]C)=[C:23]([CH3:31])[CH:24]=[C:25]3[C:30]=2[N:29]=[CH:28][CH:27]=[CH:26]3)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[C:22]([OH:32])=[C:23]([CH3:31])[CH:24]=[C:25]3[C:30]=2[N:29]=[CH:28][CH:27]=[CH:26]3)=[CH:19][CH:20]=1Komponenten
3
Versuchsvorschrift
Compound 4C was prepared following the procedure used to prepare compound 1C of Example 1, except that 8-(4-chlorophenyl)-7-methoxy-6-methylquinoline (4B) was used instead of compound 1B. LCMS-ESI+ (m/z): 270.2, 272.2 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-530ec4abf0b443f3bd7bf0e519310f01
- Quelldatensatz
- uspto-grants-2016_03
- Patentnummer
- US09296758B2