Methyl bromoacetate → (+/-)-(2-{1-[(3-tert-Butoxycarbonylaminopropyl)-(4-methylbenzoyl)-amino]-propyl}-4-oxo-4H-pyrrolo[2,1-f][1,2,4]triazin-3-yl)-acetic acid methyl ester

Reaktionsgleichung

[Br:77][CH2:78][C:79](=[O:80])[O:81][CH3:82].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH2:8][CH2:9][CH2:10][N:11]([CH:12]([CH2:13][CH3:14])[c:15]1[n:16][n:17]2[c:18]([c:19](=[O:21])[nH:20]1)[cH:22][cH:23][cH:24]2)[C:25]([c:26]1[cH:27][cH:28][c:29]([CH3:32])[cH:30][cH:31]1)=[O:33])=[O:34].[C:35]([O:36][C:37](=[O:38])[NH:39][CH2:40][CH2:41][CH2:42][N:43]([CH:44]([c:45]1[n:46]([CH2:47][c:48]2[cH:49][cH:50][c:51]([F:52])[cH:53][cH:54]2)[c:55](=[O:56])[c:57]2[cH:58][cH:59][cH:60][n:61]2[n:62]1)[CH2:63][CH3:64])[C:65](=[O:66])[c:67]1[cH:68][cH:69][c:70]([CH3:71])[cH:72][cH:73]1)([CH3:74])([CH3:75])[CH3:76]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH2:8][CH2:9][CH2:10][N:11]([CH:12]([CH2:13][CH3:14])[c:15]1[n:16][n:17]2[c:18]([c:19](=[O:21])[n:20]1[CH2:78][C:79](=[O:80])[O:81][CH3:82])[cH:22][cH:23][cH:24]2)[C:25]([c:26]1[cH:27][cH:28][c:29]([CH3:32])[cH:30][cH:31]1)=[O:33])=[O:34]