HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Thiophene-3-boronic acid → 1-isobutyl-8-(thiophen-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Thiophene-3-boronic acid | HCID 581760 | — |
| Edukt | 8-bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine | HCID 11174597 | — |
| Produkt | 1-isobutyl-8-(thiophen-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine | HCID 21984179 | — |
Reaktionsschritte
8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and thiophene-3-boronic acid were coupled according to the general procedure described in Part J of Example 1. Recrystallization from isopropanol followed by chromatography on silica gel (7% methanol in CH2Cl2) afforded 1-isobutyl-8-(thiophen-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. 235–236° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07091214B2 |
| Quelldatensatz | uspto-grants-2006_08 |
| ORD ID | ord-b5404f3d81c74fca9c293d91f37982f0 |
| Quellennotiz | uspto-grants-2006_08 |