Trifluoromethylsulfonamide → 3,4,4-trifluoro-N-[(trifluoromethyl)sulfonyl]-3-butenamide

HRID 947

Reaktionsgleichung

Reaktionsgleichung von HRID 947
[F:1][C:2]([F:8])([F:7])[S:3]([NH2:6])(=[O:5])=[O:4].[F:9][C:10](=[C:15]([F:17])[F:16])[CH2:11][C:12](Cl)=[O:13]>[OH-].[Na+]>[F:9][C:10](=[C:15]([F:17])[F:16])[CH2:11][C:12]([NH:6][S:3]([C:2]([F:8])([F:7])[F:1])(=[O:5])=[O:4])=[O:13]

Komponenten

4

Edukt 2

HCID 79001TrifluoromethylsulfonamideHCID 109207893,4,4-Trifluoro-3-butenoyl chloride

Produkt 1

HCID 153350263,4,4-trifluoro-N-[(trifluoromethyl)sulfonyl]-3-butenamideAusbeute 16,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To an ice-cooled solution of trifluoromethanesulfonamide (2.75 g, 18.4 mmol) in 7.4 mL of 2.5 N sodium hydroxide was added 3,4,4-trifluoro-3-butenoyl chloride (2.93 g, 18.5 mmol) with stirring in 2 min. The mixture was stirred in cold for 30 min and the white precipitate formed was filtered, washed with cold water (10 mL) and dried to give 0.82 g (16%) of the desired product as a white solid. m.p. 115°-120° C.

Aufarbeitung

  1. stirringThe mixture was stirred in cold for 30 min
  2. customthe white precipitate formed
  3. filtrationwas filtered
  4. washwashed with cold water (10 mL)
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e1a0dc1a113c454bac338b6a5d18d9a1
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723470

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