Hydrochloric Acid → 4-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethoxy) methyl)piperidine Hydrochloride

HRID 962471

Reaktionsgleichung

Reaktionsgleichung von HRID 962471
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)([CH2:14][O:15][CH:16]([C:19]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=2)[CH2:17][OH:18])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:39]>>[ClH:39].[C:33]1([C:11]2([CH2:14][O:15][CH:16]([C:19]3[CH:24]=[C:23]([C:25]([F:26])([F:27])[F:28])[CH:22]=[C:21]([C:29]([F:32])([F:30])[F:31])[CH:20]=3)[CH2:17][OH:18])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 105546134-Phenyl-4-[[1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy]methyl]piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 190847004-Phenyl-4-((1-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxyethoxy) methyl)piperidine Hydrochloride

Versuchsvorschrift

The compound of step (d) above was dissolved in methanolic hydrogen chloride for 2 hours then concentrated and triturated with diethyl ether and filtered to give the title compound as a white solid, m.p. 198°-202° C.

Aufarbeitung

  1. concentrationthen concentrated
  2. customtriturated with diethyl ether
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-915c52e36b3047069a931608ea87fabd
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05760018

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