Sodium Hydroxide → 4-[N-Methyl-N-(2-methylbenzoyl)amino]benzoic acid

HRID 962520Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 962520
[CH3:1][N:2]([C:12]1[CH:22]=[CH:21][C:15]([C:16]([O:18]CC)=[O:17])=[CH:14][CH:13]=1)[C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[OH-].[Na+]>CO>[CH3:1][N:2]([C:12]1[CH:13]=[CH:14][C:15]([C:16]([OH:18])=[O:17])=[CH:21][CH:22]=1)[C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 21837173ethyl 4-[N-methyl-N-(2-methylbenzoyl)amino]benzoate

Produkt 1

HCID 218370254-[N-Methyl-N-(2-methylbenzoyl)amino]benzoic acidAusbeute 67,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A sample of 1.51 g of sodium hydride (60% in oil) is washed with hexane under argon to remove the oil. To the washed sodium hydride is added 5 ml of N,N-dimethylformamide. To this mixture is added dropwise a solution of 8.69 g of ethyl 4-[(2-methylbenzoyl)amino]benzoate in 20 ml of N,N-dimethylformamide. The mixture is stirred at room temperature for 0.5 hour and then 5.23 g of methyl iodide is added. The mixture is stirred at room temperature for 16 hours. The mixture is diluted with water and extracted with dichloromethane. The extract is dried (Na2SO4), concentrated to reduce the volume and the solution filtered through a thin pad of hydrous magnesium silicate. The filtrate is concentrated in vacuo to give 11 g of an oil (1:1 mixture of product and N,N-dimethylformamide). The preceding product, ethyl 4-[N-methyl-N-(2-methylbenzoyl)amino]benzoate, (11 g) is dissolved in 30 ml of methanol and 25 ml of 2N NaOH added. The mixture is refluxed for 2 hours and the solvent removed. The residue is extracted with ether (discard) and the remaining residue dissolved in 50 ml of water. The basic solution is acidified with 2N citric acid and the solid filtered off and washed with water. The product is air dried to give 6.72 g of crystals, m.p. 187°-190° C.

Aufarbeitung

  1. temperatureThe mixture is refluxed for 2 hours
  2. customthe solvent removed
  3. extractionThe residue is extracted with ether (discard)
  4. dissolutionthe remaining residue dissolved in 50 ml of water
  5. filtrationthe solid filtered off
  6. washwashed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-33ad9a2e4278461b80653be03fa1fb55
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05760031

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