2-(3-Methoxyphenyl)-2-propanamine → N-[1-(3-Methoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamide

HRID 962679Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 962679
[C:1]([C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C@@H:12]2[C:22](=[O:30])SC2C=CC=CN=2)[CH:4]=1)#[N:2].[CH3:31][O:32][C:33]1[CH:34]=[C:35]([C:39]([NH2:42])([CH3:41])[CH3:40])[CH:36]=[CH:37][CH:38]=1>>[CH3:31][O:32][C:33]1[CH:34]=[C:35]([C:39]([NH:42][C:22]([C@H:12]2[CH2:11][CH2:10][C@H:9]3[C@H:8]4[C@H:17]([CH2:16][CH2:15][C@:13]23[CH3:14])[C@:18]2([CH3:21])[C:5]([CH:4]=[C:3]([C:1]#[N:2])[CH2:20][CH2:19]2)=[CH:6][CH2:7]4)=[O:30])([CH3:40])[CH3:41])[CH:36]=[CH:37][CH:38]=1

Komponenten

3

Edukt 2

HCID 139113102-(3-Methoxyphenyl)-2-propanamineHCID 15380265S-2pyridyl 3-cyanoandrosta-3,5-diene-17beta-thiocarboxylate

Produkt 1

HCID 67646841N-[1-(3-Methoxyphenyl)-1-methylethyl]-3-cyanoandrosta-3,5-diene-17beta-carboxamideAusbeute 64 %

Versuchsvorschrift

Following a procedure similar to that described in Example 3(b), but using S-2-pyridyl 3-cyanoandrosta-3,5-diene-17β-thiocarboxylate [prepared as described in Example 3(a)] and 1-(3-methoxyphenyl)-1-methylethylamine (prepared as described in Preparation 10b) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in a yield of 64%.

Quellen und Nachweise

ORD-Eintrag
ord-d3540467409d4715a4092511f018137d
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05760025

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