1-(4-Methoxyphenyl)-1-methylethyl azide → 2-(4-Methoxyphenyl)propan-2-amine

HRID 962700Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 962700
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([N:12]=[N+]=[N-])([CH3:11])[CH3:10])=[CH:5][CH:4]=1.[H][H]>CO.[Pt]=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH2:12])([CH3:10])[CH3:11])=[CH:5][CH:4]=1

Komponenten

5

Edukt 2

HCID 156972291-(4-Methoxyphenyl)-1-methylethyl azideHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 110082782-(4-Methoxyphenyl)propan-2-amineAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1.58 g of platinum oxide were added to a solution of 21.0 g of 1-(4-methoxyphenyl)-1-methylethyl azide [prepared as described in step (a) above] in 100 ml of methanol. The reaction mixture was then stirred for 5 hours under a stream of hydrogen. At the end of this time, the mixture was filtered, diluted with methylene chloride, and washed with an aqueous solution of sodium hydrogencarbonate, with water and with a saturated aqueous solution of sodium chloride, in that order. It was then dried over anhydrous magnesium sulfate, and concentrated by evaporation under reduced pressure, to give 17.2 g (yield 95%) of the title compound.

Aufarbeitung

  1. filtrationAt the end of this time, the mixture was filtered
  2. additiondiluted with methylene chloride
  3. washwashed with an aqueous solution of sodium hydrogencarbonate, with water and with a saturated aqueous solution of sodium chloride, in that order
  4. dry with materialIt was then dried over anhydrous magnesium sulfate
  5. concentrationconcentrated by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0b5c254a87af49df82427339d98508b1
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05760025

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