Ethyl 3-[4-(benzyloxy)-2-methylphenyl]prop-2-enoate → Ethyl 3-(4-hydroxy-2-methylphenyl)propanoate

HRID 9629

Reaktionsgleichung

Reaktionsgleichung von HRID 9629
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:11]([CH3:22])[CH:10]=1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:11]([CH3:22])[CH:10]=1

Komponenten

4

Edukt 1

HCID 67072140Ethyl 3-[4-(benzyloxy)-2-methylphenyl]prop-2-enoate2×

Produkt 1

HCID 21986481Ethyl 3-(4-hydroxy-2-methylphenyl)propanoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of ethyl 3-[4-(benzyloxy)-2-methylphenyl]prop-2-enoate (intermediate 11, 1.054 g) in ethanol (50 ml) was added to a suspension of palladium hydroxide on carbon (0.15 g) in ethanol (5 ml) under nitrogen gas. The resulting suspension was then stirred under a hydrogen atmosphere for 3 hours. The mixture was filtered through Harborlite filter aid and the pad washed with more ethanol. The combined filtrates were evaporated in vacuo to give the title compound as a clear oil.

Aufarbeitung

  1. filtrationThe mixture was filtered through Harborlite
  2. filtrationfilter aid
  3. washthe pad washed with more ethanol
  4. customThe combined filtrates were evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6d306e3fc497442fa8890ead9fcc7c78
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091237B2

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