Dimethyl Sulfoxide → HCID 19080766, Verbindung

HRID 963164Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 963164
N1C=CC=CC=1.CS(C)=O.Cl[S:12]([C:15]1[N:25]=[C:18]2[CH:19]=[C:20]([CH3:24])[CH:21]=[C:22]([Cl:23])[N:17]2[N:16]=1)(=[O:14])=[O:13].[NH2:26][C:27]1[C:28]([C:35]([F:38])([F:37])[F:36])=[N:29][N:30]([CH2:33][CH3:34])[C:31]=1[CH3:32]>C(#N)C>[CH2:33]([N:30]1[C:31]([CH3:32])=[C:27]([NH:26][S:12]([C:15]2[N:25]=[C:18]3[CH:19]=[C:20]([CH3:24])[CH:21]=[C:22]([Cl:23])[N:17]3[N:16]=2)(=[O:14])=[O:13])[C:28]([C:35]([F:37])([F:36])[F:38])=[N:29]1)[CH3:34]

Komponenten

6

Edukt 4

HCID 679Dimethyl SulfoxideHCID 1049PyridineHCID 190807555-Chloro-7-methyl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonyl chlorideHCID 19080768HCID 19080768, Verbindung

Produkt 1

HCID 19080766HCID 19080766, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Pyridine (0.31 g (3.9 mmol)) and dimethyl sulfoxide (0.03 g (0.4 mmol)) were added to a solution of 1.0 g (3.9 mmol) of 2-chlorosulfonyl-5-chloro-7-methyl-[1,2,4]triazolo[1,5-a]pyridine and 0.76 g (3.9 mmol) of 4-amino-1-ethyl-5-methyl-3-(trifluoromethyl)pyrazole in 15 mL of acetonitrile at ambient temperature with stirring. After 18 hours, the volatiles were removed by evaporation under reduced pressure and the residue was partitioned between dichloromethane and water, stirring for 10 min before separation. The solids were recovered by filtration and washed with ether. They were then resuspended in water and the mixture stirred for 30 min. The solids were recovered by filtration, washed with ether, and dried under reduced pressure at 40° C. overnight. The resulting 1.24 g (68 percent of theory) of white powder melting at 224°-226° C. was the title compound.

Aufarbeitung

  1. customthe volatiles were removed by evaporation under reduced pressure
  2. customthe residue was partitioned between dichloromethane and water
  3. stirringstirring for 10 min before separation
  4. filtrationThe solids were recovered by filtration
  5. washwashed with ether
  6. stirringthe mixture stirred for 30 min
  7. filtrationThe solids were recovered by filtration
  8. washwashed with ether
  9. customdried under reduced pressure at 40° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-6531be07998145449d48b3b428770d4b
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05763359

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