3,5-Dimethoxybenzyl chloride → 1-[4-Acetylamino-5-bromo-2-(3,5-dimethoxybenzyloxy)phenyl]-5-bromopentan-1-one

HRID 963342

Reaktionsgleichung

Reaktionsgleichung von HRID 963342
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[CH2:6]Cl.C(NC1C(Cl)=CC(C(=O)CCCCCl)=C(O)C=1)(=O)C.[C:32]([NH:35][C:36]1[C:41]([Br:42])=[CH:40][C:39]([C:43](=[O:49])[CH2:44][CH2:45][CH2:46][CH2:47][Br:48])=[C:38]([OH:50])[CH:37]=1)(=[O:34])[CH3:33]>>[C:32]([NH:35][C:36]1[C:41]([Br:42])=[CH:40][C:39]([C:43](=[O:49])[CH2:44][CH2:45][CH2:46][CH2:47][Br:48])=[C:38]([O:50][CH2:6][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=2)[CH:37]=1)(=[O:34])[CH3:33]

Komponenten

4

Edukt 3

HCID 27583953,5-Dimethoxybenzyl chlorideHCID 190818791-(4-Acetylamino-5-chloro-2-hydroxyphenyl)-5-chloropentan-1-oneHCID 190819521-(4-Acetylamino-5-bromo-2-hydroxyphenyl)-5-bromopentan-1-one

Produkt 1

HCID 190819551-[4-Acetylamino-5-bromo-2-(3,5-dimethoxybenzyloxy)phenyl]-5-bromopentan-1-one

Versuchsvorschrift

Proceeding as in Example 4, Step (b), but replacing iodomethane with 3,5-dimethoxybenzylchloride and 1-(4-acetylamino-5-chloro-2-hydroxyphenyl)-5-chloropentan-1-one with 1-(4-acetylamino-5-bromo-2-hydroxyphenyl)-5-bromo-pentan-1-one, gave 1-[4-acetylamino-5-bromo-2-(3,5-dimethoxybenzyloxy)phenyl]-5-bromopentan-1-one.

Quellen und Nachweise

ORD-Eintrag
ord-5554108108704e048f88d79e8c2a69f2
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05763458

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