3,5-Dimethylbenzyl chloride → 1-[4-Amino-5-chloro-2-(3,5-dimethylbenzyloxy)-phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride

HRID 963374

Reaktionsgleichung

Reaktionsgleichung von HRID 963374
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:20])[CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:4]([O:21][CH3:22])[CH:3]=1.[CH3:23][C:24]1[CH:25]=[C:26]([CH:29]=[C:30]([CH3:32])[CH:31]=1)CCl>>[ClH:8].[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9](=[O:20])[CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[C:4]([O:21][CH2:22][C:26]2[CH:29]=[C:30]([CH3:32])[CH:31]=[C:24]([CH3:23])[CH:25]=2)[CH:3]=1

Komponenten

3

Edukt 2

HCID 1377003,5-Dimethylbenzyl chlorideHCID 97990101-[4-Amino-5-chloro-2-methoxyphenyl]-5-(piperidin-1-yl)pentan-1-one

Produkt 1

HCID 190819881-[4-Amino-5-chloro-2-(3,5-dimethylbenzyloxy)-phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride

Versuchsvorschrift

Proceeding as in Example 12, Step (a), but replacing 1-(4-amino-5-chloro-2-methoxyphenyl)-3-{1-[2-(methylsulfonyl)aminoethyl]piperidin-4-ylpropan-1-one with 1-[4-amino-5-chloro-2-methoxyphenyl]-5-(piperidin-1-yl)pentan-1-one, and then as in Example 12, Step (b), but replacing 3,5-dimethoxybenzyl chloride with 3,5-dimethylbenzyl chloride, gave 1-[4-amino-5-chloro-2-(3,5-dimethylbenzyloxy)-phenyl]-5-(piperidin-1-yl)pentan-1-one hydrochloride, m.p. 218°-233° C.

Quellen und Nachweise

ORD-Eintrag
ord-0ea2869f10b2413c86aeb4f10f31f03f
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05763458

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