Cyclopropanecarbonyl chloride → Cyclopropanecarboxylic acid (2-cyano-ethyl)-(3-iodo-phenyl)-amide

Beteiligte Stoffe

Reaktionsschritte

1.0 g of 3-(3-iodo-phenylamino)-propionitrile are dissolved in a mixture of 25 ml of methylene chloride and 0.45 ml of triethylamine and treated dropwise at 0° with a solution of 0.42 g of cyclopropanecarbonyl chloride in 5 ml of methylene chloride. The solution is stirred at room temperature for a further 2 hrs., then poured into ice-water and extracted three times with ethyl acetate. Concentration yields 1.19 g of crude cyclopropanecarboxylic acid (2-cyano-ethyl)-(3-iodo-phenyl)-amide which is used in Example 12av) without further purification. Yield: 95%.

Herkunft & Nachweise