Hydrochloric Acid → Dihydro-7-(2-mercaptoethyl)-1-pyrindine-6,6-bisphosphonic acid

HRID 963642Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 963642
C([S:4][CH2:5][CH2:6][C:7]1[C:8]([P:24]([O:29]CC)(=[O:28])[O:25]CC)([P:16]([O:21]CC)(=[O:20])[O:17]CC)[CH:9]=[C:10]2[C:15]=1[NH:14][CH2:13][CH:12]=[CH:11]2)(=O)C.Cl>>[SH:4][CH2:5][CH2:6][C:7]1[C:8]([P:24]([OH:29])(=[O:25])[OH:28])([P:16]([OH:21])(=[O:17])[OH:20])[CH:9]=[C:10]2[C:15]=1[NH:14][CH2:13][CH:12]=[CH:11]2

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 86752760Dihydro-7-(2-acetylthioethyl)-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester

Produkt 1

HCID 86752761Dihydro-7-(2-mercaptoethyl)-1-pyrindine-6,6-bisphosphonic acid

Versuchsvorschrift

Dihydro-7-(2-acetylthioethyl)-1-pyrindine-6,6-bisphosphonic acid, tetraethyl ester (4.0 mmol) is added to 6N HCl (35 ml) and heated at reflux under nitrogen for 18 hours. The reaction mixture is then cooled and concentrated under reduced pressure. The product is obtained by recrystallizing from water and isopropanol.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux under nitrogen for 18 hours
  3. temperatureThe reaction mixture is then cooled
  4. concentrationconcentrated under reduced pressure
  5. customThe product is obtained
  6. customby recrystallizing from water and isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-1601c17761b34246994f7fce36b6dcf2
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05763611

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