Hydrochloric Acid → 2-(5-Methoxy-1,2,3,4-tetrahydro-1-naphthyl)ethanol

HRID 963691Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 963691
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][CH:8]2[CH2:13][C:14](OCC)=[O:15].[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl>O1CCCC1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][CH:8]2[CH2:13][CH2:14][OH:15]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 10538520Ethyl 2-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetateHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 106083702-(5-Methoxy-1,2,3,4-tetrahydro-1-naphthyl)ethanolAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A suspension of ethyl (5-methoxy-1,2,3,4-tetrahydro-1-naphthyl)acetate (1.02 g) and lithium aluminum hydride (0.20 g) in tetrahydrofuran (15 ml) was stirred at 0° C. for 2.5 hours. The solution was poured into cold 1N-hydrochloric acid, then the resulting mixture was filtered through the celite, and extracted with ethyl acetate. The extract was washed with brine, dried over sodium sulfate, and evaporated in vacuo to afford 2-(5-methoxy-1,2,3,4-tetrahydro-1-naphthyl)ethanol as a colorless oil (0.85 g).

Aufarbeitung

  1. filtrationthe resulting mixture was filtered through the celite
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-53d3df0b49da466c85edf482b943f878
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05763489

Notizen zur Reaktion

Wird geladen…