HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(4-(Trifluoromethyl)phenyl)ethan-1-one → 3-Dimethylamino-1-(4-trifluoromethyl-phenyl)-but-2-en-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(4-(Trifluoromethyl)phenyl)ethan-1-one | HCID 69731 | — |
| Edukt | 1,1-Dimethoxyethyl(dimethyl)amine | HCID 87835 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Produkt | 3-Dimethylamino-1-(4-trifluoromethyl-phenyl)-but-2-en-1-one | HCID 69234633 | — |
Reaktionsbedingungen
| Temperatur | 112 °C |
|---|
Reaktionsschritte
A mixture of 4′-(trifluoromethyl)acetophenone (9.8 g) and N-(1,1-dimethoxyethyl)-N,N-dimethylamine (8.2 g) was heated at 112° C. overnight, under nitrogen. The reaction mixture was cooled and concentrated giving an orange solid. Trituration with diethyl ether gave the title compound as a yellow solid
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07091237B2 |
| Quelldatensatz | uspto-grants-2006_08 |
| ORD ID | ord-1ea84c7acf084517a9e9625c59ac88bf |
| Quellennotiz | uspto-grants-2006_08 |