Sodium Azide → 9-Azidononanoic acid

Temperatur

80 °C

9-Bromo-nonanoic acid (3.82 g, 17 mmol) was dissolved in DMF (30 mL) and sodium azide (1.11 g, 17 mmol) was added. The solution was heated to 80° C. and stirred overnight. The reaction was poured onto ice and extracted with DCM (3×200 mL). The combined extracts were washed with water (3×200 mL), brine (200 mL), and dried over MgSO4. The solvent was removed in vacuo to give a clear oil 2.83 g (84% yield);

1. additionThe reaction was poured onto ice
2. extractionextracted with DCM (3×200 mL)
3. washThe combined extracts were washed with water (3×200 mL), brine (200 mL)
4. dry with materialdried over MgSO4
5. customThe solvent was removed in vacuo

ORD-Eintrag

ord-aaec078de2db4d3c861dca7845a41ca2

Quelldatensatz

uspto-grants-1998_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05767088