Diketene → HCID 23004067, Verbindung

HRID 964229Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 964229
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([O:21][CH3:22])[CH:17]=2)[CH2:12]1>C1COCC1>[CH3:22][O:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][C:15]=1[O:23][CH3:24])[CH2:12][N:11]([CH2:10][CH2:9][CH2:8][NH:7][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6])[CH2:20][CH2:19]2

Komponenten

4

Edukt 2

HCID 12661DiketeneHCID 230040563,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinepropanamine

Produkt 1

HCID 23004067HCID 23004067, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Diketene (1.41 mL, 18.3 mmol, 1.50 equiv) was added at 0° C. to a stirred solution of 2-(3-aminopropyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline (3.05 g, 12.2 mmol, 1.00 equiv) in anhydrous THF (30 mL) under argon, and stirring was continued at room temperature for 1.5 hours. The mixture was concentrated and the residual oil washed with hexane (2×100 mL) to give 4.07 g (100%) of brown oil, which was characterized spectroscopically and used for the next reaction without purification.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. washthe residual oil washed with hexane (2×100 mL)

Quellen und Nachweise

ORD-Eintrag
ord-5f45d35e1c4f49e3b48b42e538e52c13
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05767131

Notizen zur Reaktion

Wird geladen…