Acetonitrile → 2-Methylquinazoline

HRID 964569

Reaktionsgleichung

Reaktionsgleichung von HRID 964569
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

Komponenten

3

Edukt 2

HCID 6342AcetonitrileHCID 760802-Aminobenzophenone

Produkt 1

HCID 5889872-Methylquinazoline

Versuchsvorschrift

In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.

Quellen und Nachweise

ORD-Eintrag
ord-e51706796601477f9a062c3250903ba2
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05770602

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