HCID 22097613, Verbindung → Imidazole-1-butyric acid

HRID 964582Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 964582
C([O:8][C:9](=[O:18])[CH2:10][CH2:11][CH2:12][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)C1C=CC=CC=1>[C].[Pd].C(O)C>[N:13]1([CH2:12][CH2:11][CH2:10][C:9]([OH:18])=[O:8])[CH:17]=[CH:16][N:15]=[CH:14]1

Komponenten

4

Edukt 1

HCID 22097613HCID 22097613, Verbindung

Produkt 1

HCID 3055390Imidazole-1-butyric acidAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 4-(1-imidazolyl)butyric acid benzyl ester (7.4 g), 5% palladium-carbon (1.0 g) and ethanol (400 ml) was catalytically reduced at room temperature under 1 atm. After the catalyst was filtered off, the filtrate was concentrated under reduced pressure, and the residual crystal was recrystallized from ethanol, to yield 4-(1-imidazolyl)butyric acid (3.4 g, 75%) as a colorless prismatic crystal having a melting point of 125° to 126° C.

Aufarbeitung

  1. customwas catalytically reduced at room temperature under 1 atm
  2. filtrationAfter the catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customthe residual crystal was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-889aa070e6be490d8831af8cd1e25ec8
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05770602

Notizen zur Reaktion

Wird geladen…