Methyl chloroformate → Methyl 5-methylthiophene-3-carboxylate
Reaktionsgleichung
Br[C:2]1[CH:6]=[C:5]([CH3:7])[S:4][CH:3]=1.Cl[C:9]([O:11][CH3:12])=[O:10]>>[CH3:7][C:5]1[S:4][CH:3]=[C:2]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=1Komponenten
3
Versuchsvorschrift
Alternatively, initial lithiation of 3-bromo-5-methylthiophene followed by capture with methyl chloroformate gives methyl 5-methylthiophene-3-carboxylate. Free-radical bromination of the methyl group followed by treatment with an alkali azide, subsequent reduction and hydrolysis provides 5-(aminomethyl)thiophene-3-carboxylic acid (VI). ##STR38##
Quellen und Nachweise
- ORD-Eintrag
- ord-3c5661c1ca514df4b87078e618ecbe2d
- Quelldatensatz
- uspto-grants-1998_06
- Patentnummer
- US05773411
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