HCID 54034076, Verbindung → 2-(Thymin-1-ylcarbonylamino)-5-(t-butyloxycarbonyl-amino)pentanoic acid

HRID 965322Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 965322
C([O:3][C:4](=[O:29])[CH:5]([NH:17][C:18]([N:20]1[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]1=[O:22])=[O:19])[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])C>C(O)C.[OH-].[Na+]>[N:20]1([C:18]([NH:17][CH:5]([CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C:4]([OH:29])=[O:3])=[O:19])[CH:28]=[C:26]([CH3:27])[C:24](=[O:25])[NH:23][C:21]1=[O:22]

Komponenten

4

Edukt 1

HCID 54034076HCID 54034076, Verbindung

Produkt 1

HCID 190762582-(Thymin-1-ylcarbonylamino)-5-(t-butyloxycarbonyl-amino)pentanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

The product from Example 11, 15, is dissolved in ethanol (500 mL) and to this added 2M sodium hydroxide (50 mL) and the reaction stirred for 12 hours. The reaction is neutralized with 2M HC1 solution (50 mL) and evaporated to a small volume. This residue is diluted with water (250 mL) and extracted with dichloromethane (4×100 mL), dried, filtered, and evaporated to give a solid.

Aufarbeitung

  1. customevaporated to a small volume
  2. additionThis residue is diluted with water (250 mL)
  3. extractionextracted with dichloromethane (4×100 mL)
  4. customdried
  5. filtrationfiltered
  6. customevaporated
  7. customto give a solid

Quellen und Nachweise

ORD-Eintrag
ord-63e2de4bc3bf41d8b7074817254b394f
Quelldatensatz
uspto-grants-1998_06
Patentnummer
US05773571

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