HCID 22314545, Verbindung → 1-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone

HRID 966095Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 966095
[CH3:1][C:2]([NH:6][CH2:7][C:8]([C:10]1[CH:30]=[CH:29][C:13]2[O:14]C(C3C=CC=CC=3)(C3C=CC=CC=3)[O:16][C:12]=2[C:11]=1[O:31][CH3:32])=[O:9])([CH3:5])[CH2:3][CH3:4]>Cl>[OH:16][C:12]1[C:11]([O:31][CH3:32])=[C:10]([C:8](=[O:9])[CH2:7][NH:6][C:2]([CH3:1])([CH3:5])[CH2:3][CH3:4])[CH:30]=[CH:29][C:13]=1[OH:14]

Komponenten

3

Edukt 1

HCID 22314545HCID 22314545, Verbindung

Produkt 1

HCID 223145401-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

25 g of 2-(1,1-dimethylpropylamino)-1-(4-methoxy-2,2-diphenylbenzo[1,3]dioxol-5-yl) ethanone is refluxed with 50 mL of 15% methanolic hydrochloric acid for 2 hours with stirring. The solvent is distilled off under reduced pressure and the residue is dissolved in acetonitrile and combined with ethyl acetate. The precipitated crystals are suction filtered and washed with acetonitrile and diethyl ether. Yield: 15 g (92%) of the compound as the hydrochloride.

Aufarbeitung

  1. distillationThe solvent is distilled off under reduced pressure
  2. dissolutionthe residue is dissolved in acetonitrile
  3. filtrationfiltered
  4. washwashed with acetonitrile and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-1d0a380a21a44297a99d2ed5dcfd711a
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06951888B2

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