1-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone → 4-[2-(1,1-Dimethylpropylamino)-1-hydroxyethyl]-3-methoxybenzene-1,2-diol

HRID 966096Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 966096
[OH:1][C:2]1[C:3]([O:18][CH3:19])=[C:4]([C:9](=[O:17])[CH2:10][NH:11][C:12]([CH3:16])([CH3:15])[CH2:13][CH3:14])[CH:5]=[CH:6][C:7]=1[OH:8]>[Pt]=O.CO>[CH3:16][C:12]([NH:11][CH2:10][CH:9]([C:4]1[C:3]([O:18][CH3:19])=[C:2]([OH:1])[C:7]([OH:8])=[CH:6][CH:5]=1)[OH:17])([CH3:15])[CH2:13][CH3:14]

Komponenten

4

Edukt 1

HCID 223145401-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone

Produkt 1

HCID 98168584-[2-(1,1-Dimethylpropylamino)-1-hydroxyethyl]-3-methoxybenzene-1,2-diol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

6.5 g of 1-(3,4-dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone are hydrogenated with 0.1 g of platinum oxide as catalyst in 125 mL of methanol. The catalyst is suction filtered and the solvent is distilled off under reduced pressure. The residue is dissolved in ethyl acetate, the precipitated crystals are suction filtered and washed with ethyl acetate and diethyl ether. Yield: 5.5 g (85%; benzoate); melting point: 172° C.-174° C.

Aufarbeitung

  1. filtrationfiltered
  2. distillationthe solvent is distilled off under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. filtrationfiltered
  5. washwashed with ethyl acetate and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-01686959d43443dd92dfca8b55abfffa
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06951888B2

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