Methanol → Methyl 2,4,6-trimethylbenzeneacetate

HRID 966100

Reaktionsgleichung

Reaktionsgleichung von HRID 966100
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[CH2:10][C:11]([OH:13])=[O:12].[CH3:14]O>Cl>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[C:3]=1[CH2:10][C:11]([O:13][CH3:14])=[O:12]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 78123Mesitylacetic acid

Produkt 1

HCID 13524810Methyl 2,4,6-trimethylbenzeneacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

173 g (2,4,6-trimethylphenyl)acetic acid is refluxed in 131 mL of concentrated hydrochloric acid and 1.1 L of methanol for 3 hours with stirring. The solvent is distilled off under reduced pressure and the aqueous phase extracted twice with diethyl ether. The combined organic phases are extracted twice with a saturated aqueous sodium hydrogen carbonate solution and dried with sodium sulfate and the solvent is distilled off under reduced pressure. The residue is fractionally distilled. Yield: 116 g (57%); bp15: 140° C.

Aufarbeitung

  1. distillationThe solvent is distilled off under reduced pressure
  2. extractionthe aqueous phase extracted twice with diethyl ether
  3. extractionThe combined organic phases are extracted twice with a saturated aqueous sodium hydrogen carbonate solution
  4. dry with materialdried with sodium sulfate
  5. distillationthe solvent is distilled off under reduced pressure
  6. distillationThe residue is fractionally distilled
  7. custom140° C.

Quellen und Nachweise

ORD-Eintrag
ord-56a1a7153101422e84cefdf59ad6caac
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06951888B2

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