HCID 22314541, Verbindung → HCID 69725567, Verbindung

HRID 966105Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 966105
[CH3:1][C:2]([NH:11][CH2:12][C:13]([C:15]1[CH:35]=[CH:34][C:18]2[O:19]C(C3C=CC=CC=3)(C3C=CC=CC=3)[O:21][C:17]=2[C:16]=1[O:36][CH3:37])=[O:14])([CH3:10])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>Cl>[OH:21][C:17]1[C:16]([O:36][CH3:37])=[C:15]([C:13](=[O:14])[CH2:12][NH:11][C:2]([CH3:1])([CH3:10])[CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:35]=[CH:34][C:18]=1[OH:19]

Komponenten

3

Edukt 1

HCID 22314541HCID 22314541, Verbindung

Produkt 1

HCID 69725567HCID 69725567, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel2×

Versuchsvorschrift

34 g of the HCl salt of 2-(1,1-dimethyl-2-phenylethylamino)-1-(4-methoxy-2,2-diphenylbenzo[1,3]dioxol-5-yl)ethanone is refluxed in 340 mL of 15% methanolic hydrochloric acid for 2 hours. Then the solvent is distilled off under reduced pressure and the residue is dissolved in ethyl acetate. The solid precipitated is suction filtered and washed with ethyl acetate and diethyl ether. Yield: 18 g (77%, hydrochloride); melting point: 192° C.-196° C.

Aufarbeitung

  1. distillationThen the solvent is distilled off under reduced pressure
  2. dissolutionthe residue is dissolved in ethyl acetate
  3. customThe solid precipitated
  4. filtrationfiltered
  5. washwashed with ethyl acetate and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-9e9be5236d7448fa8420eea1fceeea77
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06951888B2

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