Phenol → HCID 178420509, Verbindung

HRID 967048

Reaktionsgleichung

Reaktionsgleichung von HRID 967048
Cl[C:2]1[C:11]2[N:12]=[CH:13][NH:14][C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[C:15]1([OH:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[O:21]([C:2]1[C:11]2[N:12]=[CH:13][NH:14][C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Komponenten

3

Edukt 2

HCID 996PhenolHCID 178478309HCID 178478309, Verbindung

Produkt 1

HCID 178420509HCID 178420509, Verbindung

Versuchsvorschrift

In step (4) of Reaction Scheme IV a 4-chloro-1H-imidazo[4,5-c]quinoline of Formula XX is reacted with phenol to provide a 4-phenoxy-1H-imidazo[4,5-c]quinoline of Formula XXI. The phenol is reacted with sodium hydride in a suitable solvent such as diglyme to form a phenoxide. The phenoxide is then reacted at an elevated temperature with a compound of Formula XX.

Quellen und Nachweise

ORD-Eintrag
ord-cb439e051b5b4619b811a69d245fe244
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06953804B2

Verknüpfte Notizen

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