Diaminohydroxyphosphoribosylaminopyrimidine → [(2R,3S,4R)-5-[(5-amino-2,4-dioxo-1H-pyrimidin-6-yl)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

HRID 967693

Reaktionsgleichung

NC1N=C(NC2O[C@H](CO)[C@@H](O)[C@H]2[OH:11])N=C(P(O)(OO)=O)C=1N.N[C:25]1[N:30]=[C:29]([NH:31][CH:32]2[O:38][C@H:37]([CH2:39][O:40][P:41]([OH:44])([OH:43])=[O:42])[C@@H:35]([OH:36])[C@H:33]2[OH:34])[C:28]([NH2:45])=[C:27]([OH:46])[N:26]=1>>[NH2:45][C:28]1[C:27](=[O:46])[NH:26][C:25](=[O:11])[NH:30][C:29]=1[NH:31][CH:32]1[O:38][C@H:37]([CH2:39][O:40][P:41]([OH:44])([OH:43])=[O:42])[C@@H:35]([OH:36])[C@H:33]1[OH:34]

Komponenten

Edukt 2

HCID 86589660Diaminohydroxyphosphoribosylaminopyrimidine

HCID 178508991[(2R,3S,4R)-5-[(2,5-diamino-4-oxo-1H-pyrimidin-6-yl)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

Produkt 1

HCID 54060270[(2R,3S,4R)-5-[(5-amino-2,4-dioxo-1H-pyrimidin-6-yl)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

Versuchsvorschrift

As noted above, in bacteria and fungi, GTP cyclohydrolase II (EC 3.5.4.25) catalyzes the reaction of GTP with a purine to produce 2,5-Diamino-6-hydroxy-4-(5′phosphoribosylamino)-pyrimidine; diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) catalyzes the reaction of 2,5-Diamino-6-hydroxy-4-(5′phosphoribosylamino)-pyrimidine to produce 5-amino-6-(5-phosphoribosylamino)uracil; 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) catalyzes the reaction of 5-amino-6-(5-phosphoribosylamino)uracil to produce 5-Amino-6-(5′phosphoribitylamino)uracil; lumazine synthase catalyzes the reaction of 5-Amino-6-(5′phosphoribitylamino)uracil to produce 6,7-Dimethyl-8-ribityl lumazine; and riboflavin synthase (EC 2.5.1.9) catalyzes the reaction of 6,7-Dimethyl-8-ribityl lumazine to produce riboflavin

Quellen und Nachweise

ORD-Eintrag: ord-e46db9004378449a96191b1c5f71857d
Quelldatensatz: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06955890B2

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