2,2-Dimethyl-propionic Acid 1-(2-oxo-propyl)1H-indazol-6-yl Ester → 2,2-Dimethyl-propionic Acid 1-(2-hydroxy-propyl)-1H-indazol-6-yl Ester

HRID 967711Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 967711
[O:1]=[C:2]([CH3:20])[CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][C:14](=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16])[CH:11]=2)[CH:6]=[N:5]1>CO>[OH:1][CH:2]([CH3:20])[CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][C:14](=[O:19])[C:15]([CH3:17])([CH3:16])[CH3:18])[CH:11]=2)[CH:6]=[N:5]1

Komponenten

3

Edukt 1

HCID 697528362,2-Dimethyl-propionic Acid 1-(2-oxo-propyl)1H-indazol-6-yl Ester

Produkt 1

HCID 697530822,2-Dimethyl-propionic Acid 1-(2-hydroxy-propyl)-1H-indazol-6-yl EsterAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of the product of Step B (0.91 g, 3.6 mmol) in methanol (10 ml) was treated by the procedure described for Example 1, Step C to give an oil (0.79 g, 86%) that was used in the next reaction with further purification: 1H NMR δ (CDCl3) 7.99 (s, 1H), 7.98 (s, 1H), 7.60 (d, J=8.6 Hz, 1H), 7.01 and 6.96 (dd, J=2.0 and 8.6 Hz, 1H,), 4.14–3.89 (m, 3H), 1.56 (s, 3H) 1.32 (s, 9H).

Quellen und Nachweise

ORD-Eintrag
ord-8593f5c8ab794632889b97f65aab382c
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06956036B1

Notizen zur Reaktion

Wird geladen…