Sodium Hydroxide → 4-(4-Carbamoylphenoxymethyl)piperidin-4-ol

HRID 967773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 967773
[OH-:1].[Na+].C([N:10]1[CH2:15][CH2:14][C:13]([CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=2)([OH:16])[CH2:12][CH2:11]1)C1C=CC=CC=1>C(O)C>[C:25]([C:22]1[CH:23]=[CH:24][C:19]([O:18][CH2:17][C:13]2([OH:16])[CH2:14][CH2:15][NH:10][CH2:11][CH2:12]2)=[CH:20][CH:21]=1)(=[O:1])[NH2:26]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 22291260HCID 22291260, Verbindung

Produkt 1

HCID 222912804-(4-Carbamoylphenoxymethyl)piperidin-4-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4N sodium hydroxide (6.8 mL) was added to an ethanol solution (30 mL) of the compound (2.2 g) obtained in Step 3 of Example 4 and the mixture was heated under reflux for four and half hours. The solvent was removed under reduced pressure and to the residue was added water (30 mL), and the precipitate was collected by filtration.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for four and half hours
  3. customThe solvent was removed under reduced pressure and to the residue
  4. additionwas added water (30 mL)
  5. filtrationthe precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-5276b2473bca4975ad5a3bbbfa9eaf93
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06956046B2

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