1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol → 1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride

HRID 967774Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 967774
[ClH:1].CO.[C:4]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][C:17]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)([OH:20])[CH2:16][CH2:15]2)=[CH:8][CH:7]=1)#[N:5]>CO>[ClH:1].[C:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][C:17]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)([OH:20])[CH2:16][CH2:15]2)=[CH:10][CH:11]=1)#[N:5]

Komponenten

4

Edukt 2

HCID 102916131-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-olHCID 21893726Hydrochloride methanol

Produkt 1

HCID 222912871-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

10% hydrochloric acid-methanol (0.2 mL) was added to a methanol solution (2 mL) of the compound (50 mg) obtained in Step 4 of Example 1. After the solvent was removed under reduced pressure, the residue obtained was crystallized from ether and collected by filtration to obtain the titled compound (48 mg) as crystals.

Aufarbeitung

  1. customAfter the solvent was removed under reduced pressure
  2. customthe residue obtained
  3. customwas crystallized from ether
  4. filtrationcollected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-aa80d6da31a1439097d934d520db2c33
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06956046B2

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