4-(Chloromethyl)benzoyl chloride → N-[5-(3-dimethylaminobenzamido)-2-methylphenyl]4-chloromethylbenzamide

HRID 967906Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 967906
[Cl:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[NH2:12][C:13]1[CH:14]=[C:15]([NH:20][C:21](=[O:31])[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N:28]([CH3:30])[CH3:29])[CH:23]=2)[CH:16]=[CH:17][C:18]=1[CH3:19]>>[CH3:30][N:28]([CH3:29])[C:24]1[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=1)[C:21]([NH:20][C:15]1[CH:16]=[CH:17][C:18]([CH3:19])=[C:13]([NH:12][C:7](=[O:8])[C:6]2[CH:10]=[CH:11][C:3]([CH2:2][Cl:1])=[CH:4][CH:5]=2)[CH:14]=1)=[O:31]

Komponenten

3

Edukt 2

HCID 701364-(Chloromethyl)benzoyl chlorideHCID 22057981HCID 22057981, Verbindung

Produkt 1

HCID 22291036N-[5-(3-dimethylaminobenzamido)-2-methylphenyl]4-chloromethylbenzamide

Versuchsvorschrift

4-Chloromethylbenzoyl chloride was reacted with N-(3-amino-4-methylphenyl)-3-dimethylaminobenzamide using an analogous procedure to that described in Example 37 except that the reaction product was triturated under water rather than under 2N aqueous hydrochloric acid solution. There was thus obtained the title compound; NMR Spectrum: (DMSOd6) 2.19 (s, 3H), 2.95 (s, 6H), 4.28 (s, 2H), 6.9 (d, 1H), 7.21 (m, 3H), 7.29 (d, 1H), 7.58 (d, 3H), 7.8 (s, 1H), 7.96 (d, 2H), 9.9 (s, 1H), 10.08 (s, 1H); Mass Spectrum: M−H− 420.

Aufarbeitung

  1. customwas triturated under water rather than under 2N aqueous hydrochloric acid solution

Quellen und Nachweise

ORD-Eintrag
ord-9760db3b90f34f1d898c8177ec1a2202
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06956037B2

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