Thionyl Chloride → 5,7-Dichloro-2,3-dihydro-1H-inden-1-one

HRID 968072Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 968072
S(Cl)(Cl)=O.[Cl:5][C:6]1[CH:7]=[C:8]([CH2:13][CH2:14][C:15]([OH:17])=O)[CH:9]=[C:10]([Cl:12])[CH:11]=1>C(Cl)Cl>[Cl:12][C:10]1[CH:9]=[C:8]2[C:7](=[C:6]([Cl:5])[CH:11]=1)[C:15](=[O:17])[CH2:14][CH2:13]2

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 8193053-(3,5-Dichlorophenyl)propionic acid

Produkt 1

HCID 222923465,7-Dichloro-2,3-dihydro-1H-inden-1-oneAusbeute 71,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Thionyl chloride (45.2 g) was added dropwise at 40° C. to a solution of 3-(3,5-di-chlorophenyl)propionic acid (54.8 g) in methylene chloride (200 ml). After reaction was complete, excess thionyl chloride and the solvent were removed by distillation. The oily residue was added dropwise at 40° C. to a suspension of aluminium chloride (66.7 g) in methylene chloride (200 ml). The reaction mixture was added to dilute hydrochloric acid after 18 hours at 40° C. The aqueous phase was separated off and extracted once with methylene chloride (250 ml). The combined organic phases were freed from the solvent. The residue was recrystallized from cyclohexane. 36 g of a colorless solid (m.p.: 119-120° C.) were obtained.

Aufarbeitung

  1. customAfter reaction
  2. customexcess thionyl chloride and the solvent were removed by distillation
  3. additionThe oily residue was added dropwise at 40° C. to a suspension of aluminium chloride (66.7 g) in methylene chloride (200 ml)
  4. additionThe reaction mixture was added to dilute hydrochloric acid after 18 hours at 40° C
  5. customThe aqueous phase was separated off
  6. extractionextracted once with methylene chloride (250 ml)
  7. customThe residue was recrystallized from cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-3c13883f9dfe4507a6436cafe496a417
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06956129B2

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