HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrogen Bromide → 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrogen Bromide | HCID 260 | — |
| Edukt | Dimethyl Sulfoxide | HCID 679 | — |
| Edukt | [2-Methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea | HCID 22015747 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine | HCID 22015735 | — |
Reaktionsschritte
To a solution of 1 [2-methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea (XI) in acetic acid is added hydrobromic acid, and stirring continued for about 30 min at 80° C. DMSO is then added dropwise and the reaction mixture stirred for a further 30 min at 80° C. The product (XII) 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine is isolated by conventional means.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07304058B2 |
| Quelldatensatz | uspto-grants-2007_12 |
| ORD ID | ord-58071eab15a4470e83f4aaa19074f653 |
| Quellennotiz | uspto-grants-2007_12 |