Sulfuric Acid → 3-Amino-4-methyl-2-nitrobenzoic acid

HRID 968791

Reaktionsgleichung

Reaktionsgleichung von HRID 968791
OS(O)(=O)=O.C([NH:9][C:10]1[C:11]([N+:20]([O-:22])=[O:21])=[C:12]([CH:16]=[CH:17][C:18]=1[CH3:19])[C:13]([OH:15])=[O:14])(=O)C>>[NH2:9][C:10]1[C:11]([N+:20]([O-:22])=[O:21])=[C:12]([CH:16]=[CH:17][C:18]=1[CH3:19])[C:13]([OH:15])=[O:14]

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 2434333-Acetamido-4-methyl-2-nitrobenzoic acid

Produkt 1

HCID 50773353-Amino-4-methyl-2-nitrobenzoic acid

Reaktionsbedingungen

Temperatur
115 °C

Versuchsvorschrift

To a 70% aqueous solution of H2SO4 (100 mL) is added 3-(Acetylamino)-4-methyl-2-nitrobenzoic Acid (15) (14.30 g, 60.00 mmol), and the reaction mixture heated to about 115° C. for about 30 minutes. The mixture is then cooled to ambient temperature, added to ice water (250 mL) and held at about 0° C. for about 30 minutes. The resulting solid is filtered, washed with water (100 mL), and dried to provide 3-amino-4-methyl-2-nitrobenzoic acid (16) as a rust colored solid (7.17 g, 61% yield).

Aufarbeitung

  1. temperatureThe mixture is then cooled to ambient temperature
  2. filtrationThe resulting solid is filtered
  3. washwashed with water (100 mL)
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-cad8e96057ad40d5b034b0152a1f0661
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07304084B2

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