Sulfuric Acid → 3-Amino-4-methyl-2-nitrobenzoic acid
Reaktionsgleichung
OS(O)(=O)=O.C([NH:9][C:10]1[C:11]([N+:20]([O-:22])=[O:21])=[C:12]([CH:16]=[CH:17][C:18]=1[CH3:19])[C:13]([OH:15])=[O:14])(=O)C>>[NH2:9][C:10]1[C:11]([N+:20]([O-:22])=[O:21])=[C:12]([CH:16]=[CH:17][C:18]=1[CH3:19])[C:13]([OH:15])=[O:14]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 115 °C
Versuchsvorschrift
To a 70% aqueous solution of H2SO4 (100 mL) is added 3-(Acetylamino)-4-methyl-2-nitrobenzoic Acid (15) (14.30 g, 60.00 mmol), and the reaction mixture heated to about 115° C. for about 30 minutes. The mixture is then cooled to ambient temperature, added to ice water (250 mL) and held at about 0° C. for about 30 minutes. The resulting solid is filtered, washed with water (100 mL), and dried to provide 3-amino-4-methyl-2-nitrobenzoic acid (16) as a rust colored solid (7.17 g, 61% yield).