Methanol → Methyl 2-(3-fluoro-4-methylphenyl)acetate

HRID 968973Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 968973
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8].S(=O)(=O)(O)O.[CH3:18]O>>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH3:18])=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 27746183-Fluoro-4-methylphenylacetic acid

Produkt 1

HCID 59016695Methyl 2-(3-fluoro-4-methylphenyl)acetate

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

(3-Fluoro-4-methylphenyl)acetic acid (105.3 g) was dissolved in methanol (740 ml). Concentrated sulfuric acid (9.9 ml) was added and the mixture was stirred at 85° C. for 1 hr. The reaction mixture was allowed to return to room temperature, and concentrated under reduced pressure. Water was added to the obtained residue and the mixture was extracted with ethyl acetate (1 L). The organic layer was washed successively with water, saturated aqueous sodium hydrogencarbonate solution, water and brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound (114.2 g).

Aufarbeitung

  1. customto return to room temperature
  2. concentrationconcentrated under reduced pressure
  3. additionWater was added to the obtained residue
  4. extractionthe mixture was extracted with ethyl acetate (1 L)
  5. washThe organic layer was washed successively with water, saturated aqueous sodium hydrogencarbonate solution, water and brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bd5be53b391f4c9995cf9984d894e4cc
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07304174B2

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