Sulfamide → 4-(3,4-Dichlorophenoxy)-[1,4'-bipiperidine]-1'-sulfonamide

HRID 969548Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 969548
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH2:8][CH2:7]1.[S:22](N)([NH2:25])(=[O:24])=[O:23]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([CH:12]2[CH2:13][CH2:14][N:15]([S:22]([NH2:25])(=[O:24])=[O:23])[CH2:16][CH2:17]2)[CH2:10][CH2:11]1

Komponenten

4

Edukt 2

HCID 82267SulfamideHCID 223974344-(3,4-Dichloro-phenoxy)-[1,4']bipiperidine

Produkt 1

HCID 231027624-(3,4-Dichlorophenoxy)-[1,4'-bipiperidine]-1'-sulfonamideAusbeute 80,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4-(3,4-Dichlorophenoxy)-1,4′-bipiperidine (5 g, 0.0152 mol) and sulfamide (1.45 g, 0.0152 mol) were stirred together in dioxan (150 ml) at reflux for 24 hours. The resulting mixture was cooled to ambient temperature, evaporated to dryness and the residue was triturated with ether to give the title compound as a tan solid (5 g; MS APCI 409/411 (M+H)).

Aufarbeitung

  1. temperatureat reflux for 24 hours
  2. customevaporated to dryness
  3. customthe residue was triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-d4eb8159bf6f4990b3a63ba470156b55
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07307090B2

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