{5-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol → Ethyl[4-({5-[2-fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)-2-methylphenoxy]acetate

HRID 9698

Reaktionsgleichung

Reaktionsgleichung von HRID 9698
C(OC(=O)COC1C=CC(SCC2C=C(C3C=CC(C(F)(F)F)=CC=3)OC=2)=CC=1C)C.[CH2:32]([O:34][C:35](=[O:46])[CH2:36][O:37][C:38]1[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][C:39]=1[CH3:45])[CH3:33].[F:47][C:48]1[CH:53]=[C:52]([C:54]([F:57])([F:56])[F:55])[CH:51]=[CH:50][C:49]=1[C:58]1[S:62][C:61]([CH2:63]O)=[C:60]([CH3:65])[CH:59]=1>>[CH2:32]([O:34][C:35](=[O:46])[CH2:36][O:37][C:38]1[CH:43]=[CH:42][C:41]([O:44][CH2:63][C:61]2[S:62][C:58]([C:49]3[CH:50]=[CH:51][C:52]([C:54]([F:56])([F:55])[F:57])=[CH:53][C:48]=3[F:47])=[CH:59][C:60]=2[CH3:65])=[CH:40][C:39]=1[CH3:45])[CH3:33]

Komponenten

4

Edukt 3

HCID 21986424{5-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol2×HCID 21986458Ethyl (4-hydroxy-2-methylphenoxy)acetate2×HCID 21986477Ethyl{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetate

Produkt 1

HCID 21986388Ethyl[4-({5-[2-fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)-2-methylphenoxy]acetate

Versuchsvorschrift

The title compound was prepared by a method analogous to that used for the preparation of ethyl{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetate (example 1) using ethyl(4-hydroxy-2-methylphenoxy)acetate (intermediate 7) and {5-[2-fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol (intermediate 124).

Quellen und Nachweise

ORD-Eintrag
ord-a1c3917ecc264ee88309357cfcc15257
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091237B2

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