SK&F 81297 → Dopamine

HRID 969924

Reaktionsgleichung

Reaktionsgleichung von HRID 969924
CCCN1[C@@H]2CC3C4C(=CC=CC=4NC=3)[C@H]2C[C@@H](CSC)C1.C1[C:33]2[C:28](=[CH:29][C:30]([OH:36])=[C:31]([OH:35])[C:32]=2Cl)[CH:27](C2C=CC=CC=2)[CH2:26][NH:25]C1>>[NH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([OH:35])=[C:30]([OH:36])[CH:29]=1

Komponenten

3

Edukt 2

HCID 1218SK&F 81297HCID 47811Pergolide

Produkt 1

HCID 681Dopamine

Versuchsvorschrift

HEK cells were transfected with a DNA construct encoding D1-NLS-GFP (1.5 micrograms of DNA), and incubated with the agonist pergolide (10 micromolar) for 48 hours. At 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium containing SKF-81297 (final concentration 10 micromolar). The cells were examined by confocal microscopy.

Aufarbeitung

  1. additionAt 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium

Quellen und Nachweise

ORD-Eintrag
ord-2520ff19e1914f34831d55f530327735
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07309576B2

Verknüpfte Notizen

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